Funding This study was supported by the National Key R&D Program of China (2025YFC2708300), National High Level Hospital Clinical Research Funding (2022-PUMCH-B-083) and the National Key Clinical Specialty Construction Project (U114000)
Eli Lilly's FY2024 performance was extraordinary: total revenues of USD 45.0 billion, up 32% year-on-year, driven by Mounjaro (approximately USD 11.5 billion full-year, a more than 4 increase from 2023) and Zepbound (approximately USD 4.9 billion for its first full year of obesity indication sales, including the landmark Q4 figure of USD 1.9 billion)
Mean weight loss was 13.9% on Wegovy versus 2.7% on placebo
In females specifically, IN delivery suppressed PI3K-AKT-mTOR signaling (FDR = 0.062)
American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD)
Severe cramping, extreme nausea, or dizziness warrants prompt contact