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doi: 10.1210/clinem/dgaa149 54 JohansenNJDejgaardTFLundASchluntzCFrandsenCSFormanJLet al

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When energy intake is substantially reduced, the body may conserve energy by slightly lowering core temperature and reducing peripheral blood flow

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Others may interact with anti-epileptic drugs by altering their metabolism through the liver's cytochrome P450 enzyme system, potentially reducing their effectiveness or increasing side effects