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Differentials to be considered Addison Disease Blue Nevi Ephelides (Freckles) Kaposi Sarcoma Oral Nevi Other Problems to be Considered: Amalgam tattoo Graphite tattoo Oral melanotic macule Peutz-Jeghers syndrome Physiologic pigmentation The amalgam tattoo is a frequent finding in persons who have had amalgam restorations (ie, fillings)

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Covariates in propensity score matching were adjusted for potential cofounders that occurred up to 1 day before the index event

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Therefore, modified, engineered, and designer EVs represent a new development trend in this field, and these EVs could be of great clinical value if optimized and integrated properly