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Early trial data suggest retatrutide could lead to greater average weight loss than tirzepatide, but its long-term safety, side effects, and real-world tolerability are still being studied

If you want to understand why this paper is, in the fields own terms, a big deal, you have to understand that it is the third move in a sequence whose first move shipped a $20 billion drug

That combined improvement was seen in only 16% of those receiving a placebo

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Preclinical studies have shown that SIRT1 agonists or gene overexpression can significantly improve the histopathological features of MAFLD in animal models