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They are prepared by compounding pharmacies based on physician prescriptions, and the long-term effects of sermorelin use for anti-aging and performance purposes are not yet fully understood according to medical literature

As tolerance develops and these symptoms resolve, some patients find their appetite returns more robustly than expected, potentially leading to increased food intake if not monitored carefully

They disrupt endocrine homeostasis by activating intracellular nuclear estrogen receptors (ERs) and the membrane-associated G protein-coupled estrogen receptor (GPER), while simultaneously interfering with hormone metabolic processes and epigenetic regulation