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Consequently, this intervention reduces the accumulation of histone lactylation and suppresses the expression of Fas, ultimately alleviating necroptotic cell death and renal impairment in DKD models ( 4 Autophagy 4.1 Autophagic signaling pathway Autophagy represents a preserved cellular mechanism by which cytoplasmic materials are engulfed within autophagosomes for lysosomal degradation and recycling (140)

AARS1-mediated lactylation of H3K18 and STAT1 substantially triggers renal tubular cell ferroptosis by transcriptionally activating the lipid-elongating enzyme ELOVL5 ( + levels alongside GPX4 downregulation (92)

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facilitating over-stimulated or sustained inflammatory responses with interferon and cytokine release, influencing ROS production, iron storage, platelet coagulability, cytokine production stimulation, regulation of fission and fusion, mitochondrial biogenesis, and interference of apoptosis and mitophagy (312319)

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