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Through increased labeling of BCKA-derived metabolites and increases in levels of BCAA breakdown, such as glutamate, alanine, and 3-hydroxyisobutyric acid, they discovered that tirzepatide treatment stimulated catabolism of BCAAs/BCKAs in BAT

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SCFAs may affect ileal motor function after colo-ileal reflux by causing long-duration contractions and discrete clusters of contractions (84), which can directly stimulate ileal and colonic smooth muscle contractility (85)

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