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So basically, everything surrounding obesity-related heart failure with preserved ejection fraction was improved with active therapy. No Effect on Other Heart Measurements While the reduction in LV mass and fat was significant, tirzepatide didnt affect: LV end-systolic volume LV function Left atrial (LA) volumes and function In another recent study, the SELECT trial, the GLP-1 semaglutide did show an impact on LA volumes and other markers of heart function, but no effect on LV mass

A large proportion of patients Holst found himself operating on during this period had duodenal ulcers, a disorder increasingly common in Western communities from the 1950s (Pesheva)

In a recent 21-day study in rats, SNAC was associated with the loss of beneficial gut bacteria, lower butyric acid levels, and elevated levels of inflammatory markers (13)

(Recent studies support this, too.) Metformin, another diabetes medication, has already been shown to have this effect in women with PCOS, so it isnt surprising that GLP-1 RAs would have this effect, she adds

Theyve been around for decades

Among the most talked-about medications are Phentermine and Semaglutide, two treatments that have shown promising results