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That broad action is probably one of the biggest reasons for its successits not targeting a single neuronal population or process. Most of the GLP-1 molecules cannot cross the bloodbrain barrier directly

doi: 10.1186/s13046-022-02372-8 32 ZhuJFanJXiaYWangHLiYFengZ

Toscano et al (121) demonstrated that Wistar rats exposed to copper for 30 days showed a significant increase in blood pressure and myocardial contractility

"Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice." Scientific Reports

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It is also licensed by the MHRA for weight management, following evidence from multiple large-scale clinical trials