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GPX4 is a crucial selenoprotein that converts toxic lipid hydroperoxides (L-OOH) on the cytoplasmic membrane to non-toxic lipid alcohol (L-OH) by utilizing GSH, thus preventing the accumulation of lipid peroxidation to protect cells from ferroptosis (191)

J Psychopathol

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The association of Fas with these raft markers in aged RBCs suggests that lipid rafts play a crucial role in initiating and regulating the extrinsic death pathway in erythrocytes

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(3) bioenergy supply through producing -ketoacid, which is ultimately oxidized by the tricarboxylic acid (TCA) cycle and oxidative phosphorylation for ATP production