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Wadzinski, J., Franks, R., Roane, D., and Bayard, M
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
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They performed genotyping of the A/G SNP (rs28674628) in the 3UTR of the IGF1R gene for 115 Ashkenazi Jewish BC patients, all carriers of the 185delAG BRCA1 mutation and found that all BRCA1 carriers harboring the G allele of the rs28674628 SNP were diagnosed with BC by age 45 years, whereas almost 50% of the wild type (A) allele homozygotes were BC free at that age
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