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The TRIUMPH-4 result of 28.7% weight loss is from an obesity-plus-osteoarthritis population

Importantly, this follow-up occurred in the absence of active lifestyle intervention, which the authors themselves note may have contributed to weight regain

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doi: 10.1046/j.1365-2044.2003.296812.x Hertz, H., Kristensen, H

These variations may impact the efficacy and safety of the final drug product, highlighting the importance of thorough clinical evaluation for follow-on versions of semaglutide