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Two molecules, GHK and securinine topped the list and were selected out of 1,309 bioactive molecules as the best agents capable to reverse expression of 54 gene sets overexpressed in malignant invasive metastatic colon cancer, which included node molecules YWHAB, MAP3K5, LMNA, APP, GNAQ, F3, NFATC2, and TGM2, involved in regulation of multiple biochemical pathways [ 27 ]

The most commonly reported adverse events in the Phase 2 trial were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the GLP-1 receptor agonist class

The STEP-2 trial in patients with type 2 diabetes tested both 1.0 mg and 2.4 mg semaglutide weekly