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3- Changes in Insulin and Glucose Homeostasis Affecting Nerve Function: As GLP-1 receptor agonists alter glucose metabolism, there is potential for downstream effects on neuronal excitability and peripheral nerve function
GLP-1 agonists and changes in body mass and composition in adults with overweight or obesity with or without type 2 diabetes mellitus: a systematic review and meta-analysis
In addition, several markers of metabolic disturbance are improved with tirzepatide use, including dyslipidemia, elevated blood pressure, and impaired renal function
Mishriky BM, Powell JR, Wittwer JA et al (2019) Do GLP-1RAs and SGLT-2is reduce cardiovascular events in black patients with type 2 diabetes
Case Reports and Conflicts of Interest In the absence of large-scale clinical trials, some practitioners rely on case reports and anecdotal evidence to justify the use of BPC-157
[4] [10] Data from a phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated that gastrointestinal side effects were among the most commonly reported adverse events with retatrutide, particularly at higher doses
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