And patients who could benefit - the normal-weight person with insulin resistance, fatty liver, and creeping inflammatory markers - never get offered them
More research is needed to understand why GLP-1s appear to reduce food noise, but it could be due to the reduced appetite and how the medications signal to the brain, which could help you focus less on hunger and eating throughout the day
As the second major human incretin, activated GIP receptors significantly improve systemic insulin sensitivity, reverse severe insulin resistance, and specifically reduce abnormal fat deposition in the liver, abdomen, and blood vessels, improving metabolic disorders and visceral obesity
J Headache Pain 2023;24:89
Biased agonism offers a way to tune the signal, the multi-organ distribution suggests indications still being explored, and the lesson of the antibody era, that a receptor claim is only as good as its validation, applies to every new tissue and target
doi:10.1016/j.cct.2019.105889 22
