Dehydration risk : Reduced fluid intake (from appetite suppression) combined with gastrointestinal side effects may increase dehydration risk, potentially affecting cardiovascular function and medication tolerability
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Medicina (Kaunas) 49(7):301309 Kobayashi A, Ohta T, Yamamoto M (2004) Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes
In summary, the inflamed colonic and ileal epithelia from CD patients have a dysregulation of both the pore and the leak pathway