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We believe this U-shaped dose-response curve occurs due to the possibility that low-dosed TAT-DAT NT returns the abnormally low level of dopaminergic signaling to the physiological range, and therefore normalizes the hyperactivity of SHR rats
Arimoto 2005
Andreeff M , Shank B, Hiddemann W, O'Reilly R, Clarkson BD, Melamed MR
J Biol Chem 267(6):37583763
This hormone plays a major role in fat metabolism, muscle growth, recovery, sleep, and overall vitality
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