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Harder because: you lack the deep receptor adaptation that higher-dose tirzepatide users have, meaning the GLP-1 and GIP components of retatrutide may hit you harder than expected at relatively low doses

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doi: 10.1186/s12933-023-02118-6 114 Simms-WilliamsNTrevesNYinHLuSYuOPradhanRet al