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Once a vial has been pierced, mark the date of first puncture and discard 28 days later in line with standard multiple-dose vial practice, and never use beyond the printed expiry even if the 28 days have not elapsed

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In chronic MPTP-treated primates, clioquinola metal-chelating agentreduces SN iron and ROS levels, attenuates 4-HNE accumulation, and protects DA neurons (274), indicating that iron chelation can serve as a viable strategy for PD intervention by targeting ferroptosis

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