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This would further reduce the hepatic GSH content by means of enhancing the efflux of GSH from the intercellular space, and then further aggravate the redox imbalance
WADA status : Banned for use in competition Prescription use : Not legally prescribable Online availability : Sold for research purposes only, not labeled for human consumption In countries like Australia, Canada, and parts of the EU, BPC-157 may be restricted or regulated under prescription drug frameworks
The oxidative stress caused by a decrease in GSH levels can then impact microglia function and potentially lead to a more pro-inflammatory M1 phenotype that has reduced -amyloid clearance capabilities (Vilhardt et al., 2017)
Devine or Eva F
doi:10.1093/jac/dkaa371 263
Antioxidants 10:1220
