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Patent thickets clusters of secondary patents covering formulations, manufacturing processes, dosing regimens, and metabolites can delay generic entry by years

Although the sample size was insufficient to confirm statistical significance, exploratory analysis suggested potential improvements in LVEF, patient symptoms, and brain natriuretic peptide (BNP) levels

Individual case reports Several case reports have documented blood clots in patients using semaglutide or related GLP-1 medications

Higher levels of oxalate or uric acid can make stones more likely to appear

They require no preparation and can be taken discreetly anywhere