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PD involves the progressive degeneration of dopamine-producing neurons in the substantia nigra, resulting in reduced dopamine neurotransmitter in the striatum as shown in Fig
PMID 25787873
On the contrary, MC4R agonist, setmelanotide, was approved for the rare MC4R-deficiency, BardetBiedl syndrome (BBS), with severe obesity in childhood [10, 23]
Infect Immun 53:40410
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T., Crosier, B
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