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ATTAIN-1: Eli Lilly's orforglipron 36 mg achieved 12.4% loss (27.3 lbs) at 72 weeks
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[15] [29] In October 2025, the FDA further expanded the indication for semaglutide (as Rybelsus) to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes who are at high risk for these events
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