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Supplementary Data 2 (download ZIP Official PDB reports for all three protein crystal structures

Melanotan 2 can cause various effects, from nausea and yawning to spontaneous erections and priapism

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Before the endosome fuses with lysosomes, IGF-1 LR3 can be released to the basal side through "exocytosis" and enter the lamina propria or bloodstream

MC4R, melanocortin 4 receptor-expressing

These features contribute to the progressive damage seen in the liver and can lead to fibrosis, cirrhosis, and, eventually, liver failure