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While human data is more limited, the clinical picture is consistent: semaglutide users who experience persistent GI issues often show lower microbiome diversity on stool testing than those who tolerate the medication well

Li M, Sun XH, Zhao J, Xia L, Li JC, Xu M, et al

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A number of reviews reference delays related to pharmacy preparation after prescription approval

Improving affordability, expanding equitable access, and developing care delivery models that support appropriate implementation will be essential to ensure that advances in cardiometabolic therapy translate into meaningful reductions in population-level disease burden rather than primarily benefiting those with greater resources