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Descriptive statistics were used to summarize participant characteristics, including counts and percentages for categorical variables and means (SD) for continuous variables

curcumin, which helps maintain genomic stability and modulates telomere-associated proteins

Both cagrilintide and retatrutide have specific contraindications and populations requiring special consideration [19]: Absolute Contraindications: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Previous severe allergic reaction to either compound Pregnancy or breastfeeding (insufficient safety data) Relative Contraindications Requiring Careful Evaluation: History of pancreatitis Severe gastroparesis or GI motility disorders Active gallbladder disease Severe renal impairment History of eating disorders Concurrent use of other appetite suppressants The cagrilintide dosage with retatrutide combination would carry all contraindications for both compounds, plus additional caution due to unknown interactions

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A significant focus was on developing inhibitors of insulin-regulated aminopeptidase (IRAP), a protein identified as the AT4 receptor, with the goal of enhancing metabolic stability and BBB permeability