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Further results and secondary end points are expected to be published after the completion of PIONEER 1 trial

The fate of the luminal GSSG generated is unclear

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Ramrez J, Azuaga-Piango AB, Celis R, Caete JD

Furthermore, a study revealed that tunicamycin administration in the ER caused a significant increase in cell death exclusively in wild-type mice and that administering antioxidants prior to angiotensin II prevented ER stress and apoptosis in cultured cardiac cells

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