For the experiment shown in Extended Data Fig
It is also consistent with a small clinical trial study of the GLP-1RA drug exenatide, which significantly reduced heavy drinking days and total alcohol intake in patients with obesity 12 and with a register-based study in Demark showing that GLP-1RAs (though semaglutide was not included) compared with dipeptidyl peptidase 4 inhibitors (DPP4) were associated with lower incidence of alcohol-related events in 20092017 13
Liang Y, Tang X, Zhang X, Cao C, Yu M, Wan M
Anesthesiology 93(6):15391541 Sikiric P, Gyires K, Seiwerth S et al (1993) The effect of pentadecapeptide BPC 157 on inflmammatory, non-inflammatory, direct and indirect pain and capsaicin neortoxicity
Other risk factors include the use of certain medications, and pre-existing health conditions such as digestive issues or excessive alcohol use
The problem seems to be that the associated nausea seen with Ozempic (rarely seen with Mounjaro) causes people to snack like birds on oyster crackers not almonds or eggs