Related studies have found that GLP-1RAs could limit the growth of prostate cancer by inhibiting the PI3K/AKT/mTOR and ERK/MAPK pathways, while could also limit the growth of pancreatic and prostate cancer cells by inhibiting the NF-kB pathway (210212)
Excessive IGF-1 signalling increases the activity of the insulin/IGF-1 pathway, which may accelerate some aspects of aging by leading to immunosuppression, cellular senescence, and chronic low-grade inflammation 51
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At the same time, the available studies are still early, so GLP-1s should not be viewed as a breast cancer treatment outside a clinical trial
Gradual Reimbursement Expansion In Brazil, Colombia, And Beyond Although Brazils health-technology body CONITEC deferred full semaglutide incorporation in 2024, the 2025 federal budget increased diabetes-drug funding by 15%, hinting at future tender capacity