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doi: 10.1089/omi.2011.0118 28 ZhouYZhouBPacheLChangMKhodabakhshiAHTanaseichukOet al
Conversely, in cancer, where autophagy is often upregulated to promote survival, inhibiting autophagy while simultaneously targeting the UPS could lead to the accumulation of toxic proteins and induce cell death
2022 Increasing evidence suggests that SIRT1 plays a key regulatory role at several stages of MASLD pathogenesis, identifying it as a promising therapeutic target with both systemic and stage-specific applications
In cancer, the delicate balance of proteostasis is often disrupted, leading to the accumulation of misfolded or damaged proteins, aberrant signaling pathways, and genomic instability, all of which contribute to tumorigenesis and cancer progression
Highlights PDE1B and PDE10A are critically implicated in schizophrenia pathophysiology through the disruption of cyclic nucleotides signaling pathways linked to positive, negative, and cognitive impairment
Cell Reports, 42 (4), 112388
