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The FDA approved semaglutide, branded as Wegovy, specifically for obesity in 2021 [13]
When to Call Your Doctor Most first-week symptoms are normal and manageable
Both medications require dose titration over 45 months to reach target maintenance doses
By weeks 5-8, most patients report measurable weight reduction ranging from 3-8 pounds, with continued appetite control making dietary adherence significantly easier
Patients should also call the office before changing doses, combining peptides, restarting after a long break, or using products obtained outside a legitimate medical process
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