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One study found that after injecting high doses of vitamin B12 (specifically cyanocobalamin) into rodents, the B12 stayed in the bloodstream for a relatively short period, with a half-life ranging from 20 to 50 minutes

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weekly injections is mostly absorption: oral formulations have lower bioavailability than injected versions, which the prescribing clinician accounts for when dosing

This, in turn, can compromise the structural and functional integrity of the cells nucleic acids, proteins and lipids [4]