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This means large-scale clinical trials in humans to prove safety, efficacy, and consistent dosing

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The Cochrane Collaborations tool for assessing risk of bias in randomised trials

All the results of the other pre-specified outcomes in the hierarchical analysis were also in favor of semaglutide, including the comparison of the slopes of the glomerular filtration rate (GFR) curves, major adverse cardiovascular events (MACE), and even all-cause mortality

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