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Vegetarians and vegans are particularly vulnerable, because B12 is derived from animal foods

Dosing adjustments for real-world situations The standard titration chart is a starting framework

A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo

Tesamorelin appears to act through the activation of the growth hormone-releasing hormone receptor (GHRHR), potentially stimulating endogenous growth hormone secretion and promoting lipolysis

2.3 Information sources and search strategy Three databases (PubMed, Embase, and Scopus) were searched up to 15 July 2024