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Acknowledgements This project was supported by funds from the National Key Research and Development Programme of China to TW under grant number (2023YFD1400300), the National Natural Science Foundation of China to TW under grant number U23A20197 and 31920103014, the Natural Science Foundation of Fujian Province to HC under grant number 2021J01065

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however, the ECDs in these structures had been truncated, and hence the conformation of the ECD in peptide-free or inactive states remain unknown