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Gastrointestinal side effects comparison Retatrutide has a notably higher GI side effect burden at maximum doses

And what are these new weight loss drugs anyway

The FDA has not approved these peptides for human therapeutic use, and many were placed on the withdrawn list for 503A compounding in 2023 FDA 503A bulks list

doi: 10.1016/j.bpc.2005.08.002 84 BudiALeggeFSTreutleinHYarovskyI

Study endpoints include epithelial-barrier function, tight-junction protein expression, inflammatory signaling, and mucosal tissue remodeling in models of intestinal inflammation, increased permeability, and chemically induced gastrointestinal injury

Rizzo and colleagues also noted that all three patients were taking semaglutide