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A direct detrimental incretin effect on the central nervous system could also be hypothesized and susceptible people receiving GLP-1 RAs may, in some circumstances, experience a worsening of hedonic tone predisposing psychopathology and/or self-harm ideation and/or other aspects of suicidality
When to seek help Contact your clinic or a doctor if you have severe or escalating pain, swelling that worsens after several days rather than improving, signs of infection (pus, spreading redness, fever), unusual skin discolouration, or lumps that persist beyond three to four weeks
Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction
These medications are not suitable if you have: A personal or family history of medullary thyroid carcinoma (MTC), a rare type of thyroid cancer