DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon
PubMed Barnetson RS, et al
A cold compress is another option many people find comfortable, which also helps with pain relief
Reference: Semaglutide suppresses cocaine taking, seeking, and cocaine-evoked dopamine levels in the nucleus accumbens - (
10.1007/s00125-015-3727-0 183
Recovery improvements at 3 to 4 weeks