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To understand the underlying mechanisms, inhibitors targeting the Notch pathway (DAPT) and NF-B pathway (BMS) were also applied to HUVEC and murine CLI models

PMID: 25746857 Cervellati C, Bergamini CM

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- At 30 to 40 C (summer car, warm transit): rapid degradation within hours

If they present with fatigue, brain fog, or metabolic concerns, NAD+ or Semax is the more targeted starting point

However, its important to follow proper protocols and consult with healthcare professionals.