In CRC, combining 5FU with DNA-damaging agents oxaliplatin and/or irinotecan was an empirical choice rather than a rationally designed strategy, and no new combination partners have been added since the introduction of the biological EGFR and VEGF-targeting agents in the early 2000s
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The Net Reclassification Improvement (NRI) of 0.379 and Integrated Discrimination Improvement (IDI) of 0.068 accentuate ALADDIN Scores enhanced reclassification and discrimination capacities over FIB-4
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By comparison, QCN gel exhibited a pH of 6.7 but, lacking HA vesicles, was more prone to environmental fluctuations