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Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]

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What the evidence supports GLP-1 receptor agonists have been in clinical use for type 2 diabetes since 2005, which means the medicine class has a longer real-world safety record than the weight-management licences suggest