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The collapse of both astrocyte and microglia into pro-inflammatory states due to depletion of GSH, leading to sustained neuroinflammation and oxidative stress, is observed in many neurodegenerative diseases (Mandal et al., 2022

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Given that efficacy is related to trough levels, more frequent dosing may be sensible in patients with augmented renal clearance (e.g., 1 gram IV q8hrs rather than 1.5 grams q12hrs)

But she cautioned against rushing to the store to pick up a bottle of acetyl-L-carnitine and self-medicating for depression