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[12] Metformin: Anchor in the GLP-1 RA Care Continuum Journey The mechanistic, real-world, clinical trials and pharmacovigilance evidence landscape suggests metformin as the potential anchor pharmacological agent across the entire GLP-1 RA care continuum, during therapy and beyond.Table 1 summarises the key potential outcome benefits at each phase

Patients who reach 2.4 mg with manageable side effects are positioned for the longest part of the weight loss curve, which spans the next several months at the maintenance dose

Il intervient dans de nombreux processus biochimiques

The twice-daily dosing requirement and gastrointestinal side effects have limited its use compared to newer, longer-acting alternatives

It is important to distinguish between pain directly caused by the medication and pain that may arise indirectly through physiological changes associated with treatmentsuch as weight loss, altered body composition, or changes in physical activity levels