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doi:10.1016/j.jns.2021.120004

At a later stage, MET is predominantly pre-synaptic, reflecting a dynamic regulation of MET expression depending on the post-natal age of the examined mice ( FIGURE 2 The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur ( Rhesus monkey) ( Beyond Neurotrophic Functions: HGF-MET Play a Role in Synaptogenesis and Neuroplasticity Circumstantial evidence indicates that MET is implicated in the synapse formation

So, the route of administration matters

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