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Homocysteine metabolism
If there is insufficient (or no) B12 in bloodstream, or it is not linking well with B12 at this stage, your MMA will increase in your bloodstream, and carry on increasing until B12 makes the journey and the required links
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The "as needed" approach reflects that NAD+ is a coenzyme, not a receptor agonist there's no desensitization concern in the same way
J.AbhijitK.RosalbaP
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