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DAA, particularly neurotoxic C3 + reactive astrocytes, can be induced by factors such as IL-1, TNF-, and C1q, released from activated neuroinflammatory microglia, as mentioned (Liddelow et al., 2017)

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Vitamin B12, also known as cobalamin, plays a crucial role in: Red blood cell production Nerve function DNA synthesis Energy production and metabolism A deficiency in Vitamin B12 can lead to fatigue, anemia, nerve damage, and cognitive issues

Clinical Trial Findings: Quantification of IL-6, MDA, and GSH Levels in T2DM Subjects Levels of IL-6 were quantified in plasma and PBMCs isolated from T2DM subjects at pre- and post- L-GSH/or placebo supplementation