Both oral and injectable semaglutide carry similar risks, including: Acute pancreatitis Diabetic retinopathy complications (diabetes-related vision changes) Hypoglycemia (low blood sugar), especially when used with insulin Kidney or gallbladder issues Severe gastrointestinal reactions Allergic reactions Pulmonary aspiration during general anesthesia or deep sedation Additionally, Wegovy carries warnings for increased heart rate and suicidal behavior or ideation
Cytokine modulation Beyond its effects on Tregs, thymosin alpha-1 directly reduces the production of IL-1beta and TNF-alpha, two cytokines central to psoriasis pathology
Recurring infections might suggest an underlying issue, like a change in blood sugar levels or immune response, which your doctor can help address
Semaglutide can also help reduce anxiety, low mood, and mental fatigue that commonly accompany ongoing weight challenges
A 2024 study published in JAMA Ophthalmology examined data from more than 37 million adults and found an association between semaglutide use and NAION, an association Novo Nordisk and Eli Lilly have disputed, but one that legal teams are citing as foundational to these claims
2020;16(Suppl 9):e042909
