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The first GLP-1 medication, called Byetta (exenatide) , was approved by the FDA in 2005 for type 2 diabetes
Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation
Ekstedt M, Hagstrm H, Nasr P, Fredrikson M, Stl P, Kechagias S, Hultcrantz R
Importantly, hemodynamic effects - modest reductions in heart rate (+2-4 bpm) and blood pressure decreases - are generally well tolerated and beneficial in this population
Liver Enzymes (ALT, AST, GGT): Optimal ALT is below 25 U/L
As a result, reviewers generally describe these findings as suggestive rather than definitive
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