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This work was supported by grants from the National Natural Science Foundation of China (32270727, 32000141), the Natural Science Foundation of Fujian Province (2021J01029) and the Fundamental Research Funds for the Central Universities (20720210094) to Y.C., grants from the Research Grants Council of Hong Kong (CRS_CUHK405/23, AoE/M-402/25-N, AoE/M-05/12, CUHK14106823, C4033-19E, C4002-20W, C4002-21EF, C2003-22WF, R4005-18, C4014-23G, G-CUHK409/23 and Senior Research Fellow Scheme SRFS2122-4S01), the Chinese University of Hong Kong (CUHK) Research Committee, and Science Faculty to L.J., as well as grants from the State Key Laboratory of Chemical Biology and Drug Discovery (PolyU), the Research Grants Council (RGC) (Hong Kong) (14105517) and the Hong Kong Polytechnic University (University Grants Committee) (P0046618) to W.C.Y.L

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The honest version of the economic argument is: we have an evidence gap because the incentives are broken