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88 STAT3 forms complexes with TOX, directly binding promoters of inhibitory receptors such as PD-1, TIM-3, and LAG-3, increasing chromatin accessibility and enforcing an exhausted phenotype

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Tumor cells, in their quest for survival and proliferation, generate abnormally high levels of oxidative stress, partly due to increased cellular redox buffer GSH (87)

While ROS are essential for pathogen clearance, excessive and unregulated production leads to widespread cellular and tissue injury (Figure 3) (Mantzarlis et al., 2017)

Water sourced from non-pharmaceutical channels even if labeled "sterile" may not meet this threshold